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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NUAK1
All Species:
10.61
Human Site:
S500
Identified Species:
17.95
UniProt:
O60285
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.23
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O60285
NP_055655.1
661
74305
S500
S
N
D
V
M
G
S
S
I
P
S
P
S
P
P
Chimpanzee
Pan troglodytes
XP_001161041
661
74289
S500
S
N
D
V
M
G
S
S
I
P
S
P
S
P
P
Rhesus Macaque
Macaca mulatta
XP_001098986
667
74748
S506
S
N
D
V
M
G
S
S
V
P
S
P
S
P
P
Dog
Lupus familis
XP_538417
666
74288
G505
S
Q
D
G
P
G
S
G
L
P
S
P
S
P
P
Cat
Felis silvestris
Mouse
Mus musculus
Q641K5
658
73643
G501
S
N
D
V
V
I
S
G
G
L
S
S
P
P
P
Rat
Rattus norvegicus
Q66HE5
630
69934
L479
P
S
E
S
G
E
L
L
D
A
G
D
V
F
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508265
661
73136
G500
S
D
A
G
P
G
A
G
D
T
S
P
G
A
G
Chicken
Gallus gallus
Q9IA88
798
88848
V492
Q
H
A
P
P
C
I
V
I
S
S
S
A
S
P
Frog
Xenopus laevis
NP_001088596
570
64876
N419
Q
T
C
H
T
D
S
N
I
C
D
E
P
A
P
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
A822
V
L
G
K
Q
L
S
A
D
N
A
E
T
H
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649991
1427
153426
R1123
I
K
T
T
L
Q
A
R
A
T
S
L
E
P
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q9TW45
1192
126331
K666
T
G
I
T
G
T
R
K
I
A
D
P
K
G
R
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P92958
512
58671
T360
S
G
S
N
P
M
R
T
P
E
A
G
A
S
P
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
R479
T
S
L
P
Q
I
H
R
A
N
M
L
A
Q
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
97.9
91.7
N.A.
90.9
55.6
N.A.
84.2
26.1
48.5
23.5
N.A.
24.3
N.A.
22.4
N.A.
Protein Similarity:
100
99.8
98
94.4
N.A.
93.8
68
N.A.
88
42.8
61.4
36.2
N.A.
33.6
N.A.
35.8
N.A.
P-Site Identity:
100
100
93.3
66.6
N.A.
53.3
0
N.A.
26.6
20
20
6.6
N.A.
13.3
N.A.
13.3
N.A.
P-Site Similarity:
100
100
100
73.3
N.A.
60
13.3
N.A.
40
33.3
26.6
26.6
N.A.
26.6
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.1
26.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
49.3
46.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
15
0
0
0
15
8
15
15
15
0
22
15
0
% A
% Cys:
0
0
8
0
0
8
0
0
0
8
0
0
0
0
0
% C
% Asp:
0
8
36
0
0
8
0
0
22
0
15
8
0
0
0
% D
% Glu:
0
0
8
0
0
8
0
0
0
8
0
15
8
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% F
% Gly:
0
15
8
15
15
36
0
22
8
0
8
8
8
8
15
% G
% His:
0
8
0
8
0
0
8
0
0
0
0
0
0
8
0
% H
% Ile:
8
0
8
0
0
15
8
0
36
0
0
0
0
0
0
% I
% Lys:
0
8
0
8
0
0
0
8
0
0
0
0
8
0
8
% K
% Leu:
0
8
8
0
8
8
8
8
8
8
0
15
0
0
0
% L
% Met:
0
0
0
0
22
8
0
0
0
0
8
0
0
0
0
% M
% Asn:
0
29
0
8
0
0
0
8
0
15
0
0
0
0
0
% N
% Pro:
8
0
0
15
29
0
0
0
8
29
0
43
15
43
58
% P
% Gln:
15
8
0
0
15
8
0
0
0
0
0
0
0
8
0
% Q
% Arg:
0
0
0
0
0
0
15
15
0
0
0
0
0
0
8
% R
% Ser:
50
15
8
8
0
0
50
22
0
8
58
15
29
15
8
% S
% Thr:
15
8
8
15
8
8
0
8
0
15
0
0
8
0
0
% T
% Val:
8
0
0
29
8
0
0
8
8
0
0
0
8
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _